I think the basic 2 to 3 ratio (as in 10" x 15") applies even there. However, to assure that you don't lose essential details, the original art should perhaps be done in a 6" x 9" image area (for comics pages, that is). Most ashcans I've seen are a print size of 5 1/2" x 8 1/2" (or 8 1/2" x 11" pages folded in half, then stapled).
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